Epigallocatechin -3-gallate 가 지방세포 분화와 포도당 수송 및 지질대사 유전자에 미치는 영향

Green tea catechins have been shown to promote loss of body fat and to inhibit growth of many cancer cell types by inducing apoptosis. The objective was to determine if epigallocatechin-3-gallate (EGCG) has ability to reduce differentiation in 3T3-L1 adipocytes and alter expression of aberrant lipid metabolism-related genes in HepG2 hepatocytes. EGCG attenuated differentiation related gene expressions of adipocytes likely due to retarding glucose uptake in 3T3-L1 cells. EGCG decreased the concentration of cholesterol in HepG2 cell, resulting in the similar degree of suppression in apoB 100, and of enhancement in LDL receptor and HMG-CoA reductase mRNA levels. These results demonstrated that EGCG can act directly to inhibit differentiation of 3T3-L1 adipocytes and reduce abnormality in lipid metabolism-related genes in HepG2 hepatocytes, thus, could be a potent adjuvant in the treatment of obesity and metabolism disease.